Wounds can be healed faster and scaring can be reduced substantially if one of the genes is suppressed. This specific gene normally switches on within the wounded cells and cause scars.
This recent study finding of scientists at the ‘University of Bristol’ has several implications for millions of people who are suffering from organ tissue damage problems just because of some illness or abdominal surgery. It would also help many others who are wound victims. Findings of this research study will be published in the “Journal of Experimental Medicine” on 26 January.
Immediately upon damage occurs to the skin there is a formation of blood clot. Cells present below the wound start repairing the damage and this normally results in to scarring.
Scarring is a natural tissue repairing process segment subsequent to the healing of the skin after a cut or burn. Scarring is just not limited to skin only. It rather covers trivial like grazed knee to chronic like diabetic leg ulcers. It may also include tissues scar resulting from repair like an alcohol-induced liver damage leading to fibrosis and liver failure. Post -abdominal surgeries scars have greater risks leading to major complications.
White cells receive inflammatory response when tissue damage occurs. This response activates white cells to protect skin from infection and starts killing the microbes. Simultaneously, the process of formation of layers of collagen also begins. Collagen layers help the process of healing but remain away from the skin and this finally forms a scar.
Professor Paul Martin and colleague researchers at the’ University of Bristol’ have been successful in identifying the ” Osteopontin (OPN)”, the gene that triggers scarring. If applied a special gel which suppresses the “Osteopontin (OPN)” to the wound, it helps accelerating the healing process reduces scarring. This process causes an increase in the regeneration of blood vessels around the wound and then the tissue reconstruction gets faster.
Along with the “osteopontin”, the white blood cells and the chemical signals are currently prime focus areas on the basis of which medicines would be developed in near future. “This will improve healing of skin wounds and other organs where fibrotic tissue repair can be debilitating” said Professor Paul Martin.
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